Bone response to orthodontic forces in diabetic Wistar rats

VILLARINO MARIANO ENRIQUE; LEWICKI MARIANELA; UBIOS ANGELA MATILDE

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS

MOSBY-ELSEVIER

Año: 2007 vol. 139 p. 76 - 82

0889-5406

Introduction: Patients with type 1 diabetes have shown decreased bone mineral density (BMD) values. Theneed for orthodontic treatment in diabetic patients is usually associated with occlusal problems and the occurrenceof abnormalities in the development of the jaws. The aim of this study was to analyze bone response ofinsulin-treated and untreated diabetic rats after applying orthodontic forces. Methods: Wistar rats were dividedinto 3 groups: experimental orthodontics, experimental diabetes and orthodontics, and experimental diabetestreated with insulin and experimental orthodontics. Orthodontic forces were applied the first day of the seventhweek. Forty-eight hours after placement, all the animals were killed, and the maxillae were excised andprocessed using routine histologic techniques. Results: Bone activity in the periodontal cortex of the dental alveolusshowed a significant decrease in bone formation and erosive areas in diabetic animals as compared withcontrols. A recovery of these parameters could be observed in the group with experimental diabetes treated withinsulin and experimental orthodontics. Bone volume in the interradicular bone showed no significant differencesamong groups. Conclusions: People with diabetes should not receive orthodontic treatment until their metabolicstatus normalizes. Bone response to orthodontic forces in insulin-treated diabetic subjects does notdiffer significantly from that observed in healthy subjects. (Am J Orthod Dentofacial Orthop 2011;139:S76-82)