INVESTIGADORES
TOMAS GRAU Rodrigo HernÁn
congresos y reuniones científicas
Título:
A new cellular model to study a-synuclein aggregation, seeding and phosphorylation
Autor/es:
CHEHÍN, R; GONZALEZ LIZARRAGA, MF; ÁVILA, C; PLOPER, D; SOCIAS, B; TOMAS GRAU, RH; SEQUEIRA, S; MELLA LOPEZ, R; VILLACÉ LOZANO, P; MICHELE, P; SALADO, C; RAISMAN VOZARI, R
Lugar:
Barcelona
Reunión:
Conferencia; International Conference on Alzheimer's and Parkinson's diseases and related neurological disorders; 2022
Resumen:
We aimed to develop a reliable cellular model to test and validate events of Lewy body (LBs) formation and maturation, to be used as a platform for screening candidate drugs for Parkinson?s disease (PD) and other synucleophathies. LB formation is a complex process that has recently been proposed as, rather than simply α-syn fibrillization, a major driver of PD pathogenesis.. The growth and maturation of LB involves an intricate relationship between α-syn fibrillization, posttranslational modifications, and interaction with membranous organelles.