INVESTIGADORES
TOMAS GRAU Rodrigo HernÁn
congresos y reuniones científicas
Título:
PEGASUS: A NOVEL DOPAMINE AGONIST WITH NEUROPROTECTIVE EFFECT
Autor/es:
CHEHÍN, R; PLOPER, D; PERNICORE, A; MANZANO, V; SOCIAS, B; ÁVILA, C; VERA PINGITORE, E; CHAVES, S; KOLENDER, A; TOMAS GRAU, RH; GONZALEZ LIZARRAGA, MF; LUONG, M; VARELA O
Lugar:
Paris
Reunión:
Congreso; Federation of European Neuroscience Societies; 2022
Resumen:
Continuous and safe delivery of dopamine (DOPA) across the blood brain barrier (BBB) is a main obstacle for successful substitution therapy in Parkinson's disease. Our aim is to take advantage of the well-known capacity of doxycycline (DOXY) to cross the BBB1, together with its neuroprotective activity2 , in order to obtain a DOXY-DOPA hybrid molecule, which we call Pegasus, with potential application in Parkinson's disease.
