RESCUE OF DOPAMINE NEURONS FROM IRON-DEPENDENT FERROPTOSIS BY DOXYCYCLINE AND DDMC, A NOVEL DERIVATIVE OF DEMECLOCYCLINE LACKING ANTIBIOTIC ACTIVITY.

TOURVILLE, A; VIGUIER, S; RAMIREZ, P; DOS-SANTOS PEREIRA, M; TOMAS GRAU, RODRIGO H.; BRUNEL, JM; DEL-BEL, E; CHEHÍN, R; FERRIE, L; FIGADÈRE, B; RAISMAN VOZARI, R; MICHELE, P

Paris

Congreso; Federation of European Neuroscience Societies; 2022

Doxycycline (DOX) an old tetracycline (TC) antibiotic primarily used for skin problems recently demonstrated its efficacy in model systems that relate to Parkinson disease (PD) neurodegeneration. The aim of the present work was two-fold: (i) establish a model system to better characterize DOX-mediated neuroprotection and (ii) take advantage of this system to discover novel TCs having better protective effects than DOX and no antibiotic activity.