CRH acts anxiolytic by modulating dopamine release through a subset of GABAergic long-range projection neurons

DEDIC N,; KUEHNE C,; JAKOVCEVSKI M,; HARTMANN J,; GENEWSKY A; GOMES KS; ANDERSHANOVA E; POEHLMANN M,; CHANG S,; KOLARZ A,; VOGL AM,; METZGER MW; SCHMIDT M; ALMADA R, ; RESSLER KJ,; WOTJAK CT,; GRINEVICH V,; CHEN A; SCHMIDT M; WURST W,; REFOJO D,; DEUSSING JM,

NATURE NEUROSCIENCE.

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2018 vol. 21 p. 803 - 807

1097-6256

The interplay between corticotropin-releasing hormone (CRH)and the dopaminergic system has predominantly been studiedin addiction and reward, while CRH?dopamine interactions inanxiety are scarcely understood. We describe a new populationof CRH-expressing, GABAergic, long-range-projectingneurons in the extended amygdala that innervate the ventraltegmental area and alter anxiety following chronic CRH depletion.These neurons are part of a distinct CRH circuit that actsanxiolytically by positively modulating dopamine release.