INVESTIGADORES
REFOJO Damian
artículos
Título:
Molecular mechanisms of action of some immunosuppressive drugs
Autor/es:
LIBERMAN AC,; DRUKER J,; REFOJO D,; ARZT E,
Revista:
MEDICINA
Editorial:
Fundación Revista Medicina
Referencias:
Año: 2008 p. 455 - 464
ISSN:
0076-6046
Resumen:
A number of natural and synthetic substances are used in the treatment
of immunological disorders. The immunosuppressive drugs are widely
utilized in clinical treatments of autoimmune disorders, in the
prevention of transplant rejection as well as in non-autoimmune diseases
such as allergy. The design of immunosuppressive therapies is based on
the control of the exacerbated immune response. The pathophysiologic
mean of this concept is to modulate the action of mononuclear cells,
being T cells the main targets. Immunosuppressive agents have different
molecular targets, and an important drawback in their use is that they
also inhibit the normal immune system response. Depending on their mode
of action, immunosuppressive drugs can be classified in four different
groups: antinflammatory drugs of the corticosteroid family, inhibitors
of the calcineurin pathway, cytototoxic or antiproliferative drugs and
specific antibodies. In this article, we focus on the molecular action
of immunosuppressive drugs such as steroids, cyclosporine, tacrolimus,
azathioprine, cyclophosphamide, sirolimus, mycophenolate mofetil,
leflunomide and specific antibodies, providing data to characterize and
improve the use of these agents.
