INVESTIGADORES
REPETTO Evangelina
capítulos de libros
Título:
Carbohydrates mimetics: enzyme inhibitors and target molecules in several diseases”
Autor/es:
EVANGELINA REPETTO; CUSTODIANA COLMERAREZ LOBO; VERONICA MANZANO
Libro:
Biological Macromolecules: Bioactivity and Biomedical Applications
Editorial:
Academic Press
Referencias:
Año: 2022; p. 547 - 577
Resumen:
Carbohydrates are essential biomolecules and an important component of the biomass. They are essential biomolecules for life, with different functions that goes from the storage of energy to the mediation of a variety of biological processes such as signaling and cell adhesion, cellular recognition, growth and differentiation, fertilization, angiogenesis, intercellular communication. Carbohydrates are highly functionalized molecules with interesting properties, great structural diversity and easily tunable. They have found applications in diverse areas such as agriculture, biomedicine, pharmaceutical and for the design of new materials. In the area of the biomedicine, the search of new compounds for the design of drugs and therapeutics is a main task and, in this sense, carbohydrate have emerged as promising materials for this aim.Glycosidases played a predominant role in many biological processes and their inhibition might constitute an interesting strategy for the development of new therapeutics to treat diverse diseases. Glycomimetics are natural or synthetic carbohydrate analogs which are generally used for the study and characterization of many biochemical processes in which carbohydrates mediate. They also act as inhibitors of many enzymes, specially glycosyl hydrolases or glycosidases. These glycomimetics are characterized for having a structural change (isosteric modification) in contrast with their natural counterpart which may include the substitution of the ring oxygen or either replacement of the glycosidic oxygen, with other atoms as nitrogen, carbon or sulfur. Also, an in the search of new inhibitors for the glycosidases, the design of multivalent compounds is being widely studied as these compounds have multiple reactive points which can interact with the enzyme. Similarly, other macromolecular systems or polysaccharides have been widely studied as potential inhibitor for glycosidases.