INVESTIGADORES
REPETTO Evangelina
artículos
Título:
Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents
Autor/es:
ISABEL PERILLO; EVANGELINA REPETTO; MARÍA CRISTINA CATERINA; ROSANA MASSA,; GABRIEL GUTKIND; ALEJANDRA SALERNO
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
ELSEVIER
Referencias:
Año: 2005 vol. 40 p. 811 - 815
ISSN:
0223-5234
Resumen:
Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds weresynthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means oftheir 1H- and 13C-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative andGram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations ofactive compounds were determined.