INVESTIGADORES
CID Mariana Paula
artículos
Título:
Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety
Autor/es:
LUCILA GUADALUPE CACERES; CID MARIANA; SOLEDAD LUCÍA URAN; ZORRILLA ZUBILETE MA; NANCY ALICIA SALVATIERRA; LAURA RUTH GUELMAN
Revista:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2013
ISSN:
0091-3057
Resumen:
Therefore, the aim of the present study was to investigate whether the behavioral differences observed in young animals irradiated at birth might be underlain by early changes in PKCß1 levels which, in turn, could lead to changes in hippocampal GABAergic neurotransmission. Male Wistar rats were irradiated with 5 Gy of X rays between 24 and 48 hours after birth. Different pharmacological markers related to the affected behavioral tasks were assessed in control and irradiated hippocampus at 15 and 30 days, namely GABAA receptor, GAD65-67, ROS and PKCß1. Results showed that all measured parameters were increased in the hippocampus of 30-days-old irradiated animals. In contrast, a decrease in the levels of PKCß1 in the hippocampus of 15-days-old irradiated animals was found. These data suggest that PKCß1 might constitute a primary target for neonatal radiation damage on the hippocampus. Therefore, it could be hypothesized that an initial decrease in the levels of this protein can trigger a subsequent compensatory increase that, in turn, could be responsible for the plethora of biochemical changes that might underlie the previously observed behavioral alterations.