INVESTIGADORES
GASTÓN MarÍa Soledad
artículos
Título:
Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.
Autor/es:
GASTÓN M.S.; CID, M.P.; VÁZQUEZ, A.M.; DECARLINI, M.F.; DEMMEL, G.I.; ROSSI, L.I.; AIMAR, M.L.; SALVATIERRA N.A.
Revista:
PHARMACEUTICAL BIOLOGY
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Lugar: Londres; Año: 2016
ISSN:
1388-0209
Resumen:
Context: Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In Persian traditional medicine and others it is used for the relief of anxiety and insomnia. The systemic administration of hydro-alcoholic and aqueous extract of aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect. Objective: To study the effects of intracerebroventricular administration of essential oil from coriander seeds and its major component linalool on locomotor activity and emotionality of neonatal chicks.Materials and methods: The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (< 80% linalool composition). The effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 μg/chick) vs saline and a sedative diazepam dose (17.5 μg/chick, standard drug) were observed in an Open-Field test for 10 min.Results: Doses of 8.6 and 86 μg from coriander oil and linalool significantly decreased the squares crossed number (p < 0.05), attempted escapes (p < 0.05), defecation numbers (p < 0.05) and distress calls (p < 0.05) and significantly increased the sleeping posture time (p < 0.05) in an Open-Field test compared to saline group although were similar to chicks injected with sedative diazepam dose. Discussion and Conclusion: The results obtained herein indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 μg doses in neonatal chicks. This effect may be due to monoterpene linalool that also induced a similar sedative effect, and therefore could be considered as a potential therapeutic agent similar to diazepam.