INVESTIGADORES
GRAS Diana Ester
congresos y reuniones científicas
Título:
Expression of Trichophyton rubrum genes during ex vivo human skin infection
Autor/es:
PERES NT; GRAS DE; SANCHES PR; FALCÃO JP; ROCHA LB; ROSSI MA; MAZUCATO M; ROSSI A; PRADE RA; MARTINEZ-ROSSI NM
Lugar:
Edimburgo
Reunión:
Conferencia; 9th European Conference on Fungal Genetics; 2008
Institución organizadora:
Federation of European Microbiological Societies
Resumen:
Trichophyton rubrum is a pathogenic fungus commonly isolated from human nails and skin lesions worldwide, causing infection in both healthy and immunocompromised hosts. Usually, during the pathogenic process in dermatophytosis no living tissue is invaded, with the keratinized stratum corneum being simply colonized. However, the presence of the fungus and its metabolic products may induce allergic and inflammatory eczematous responses in the host, and the infection may be invasive in immunodeficient hosts. Although it is a wide spread infection, little is known about the pathogenic process in dermatophytosis. So, the analysis of T. rubrum responses during infection could reveal the molecular alterations required for the organism to survive in the host milieu. Here, we used the subtractive suppressive hybridization (SSH) methodology to identify genes potentially related to fungal–host interaction, analyzing the transcriptome of T. rubrum during an ex vivo human skin infection. The up-regulated genes during skin infection provide insights into metabolic adaptations performed by T. rubrum during host infection, and these findings encourage further studies about T. rubrum pathogenesis.