INVESTIGADORES
RODRIGUEZ Andrea Paola
congresos y reuniones científicas
Título:
Initial calcification of bone formation in ectopic and osteogenic tissues induced by BMP-collagen composite
Autor/es:
GUNDUZ M, INOUE M, TSUJIGIWA H, GUNDUZ E, SAKAE T, NAGAOKA N, SIAR C, VILORIA I, LEGEROS R, NAGATSUKA H, RODRIGUEZ AP, HAN PP, CENGIZ B, NAGAI N
Lugar:
Niigata (Japan)
Reunión:
Simposio; The 8th International Symposium on Biominerlization; 2001
Resumen:
The pattern of initial calcification is different in induced bone formation at heterotopic sites. In our study (experiments 1, 2 and 3), BMP and atelocollagen complex was implanted into subcutaneous and subperiosteal tissues of rats. Initial calcification multipotentially started in matrix vesicles of osteoid tissue as well as in carrier collagen fibers. Bone formation occurs either via preexisting cartilage or directly according to the geometry of carriers used and environmental conditions. In this study, we conducted an ultrastructural analysis of subcutaneously implanted both bovine extracted BMP and rhBMP with collagen carriers and subperiosteally implanted rhBMP-collagen composites in rats to understand the effects of carrier and environmental conditions on bone formation