INVESTIGADORES
RODRIGUEZ Andrea Paola
congresos y reuniones científicas
Título:
Effect of sintering time of CaTiO3-CaCO3 in osteoblastic response of KUSA/A1 cells
Autor/es:
ANDREA P. RODRIGUEZ; SANCHEZ M.A.; INOUE M.; FELICE B.; NAGATSUKA H.; MADRID R.E.; FELICE C.J.; TSUJIGIWA H.
Lugar:
Paraná, Entre Ríos
Reunión:
Congreso; CLAIB 2014; 2014
Resumen:
In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ??calcium titanate with calcium carbonate?? (CaTiO3?CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3-CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that CaTiO3?CaCO3 material sintered during 30 min, has better influence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary findings indicate that CaTiO3?CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.