INVESTIGADORES
RODRIGUEZ Andrea Paola
artículos
Título:
In vivo response of Osteoblast-like and Odontoblast-like cells in intraperioneal diffusion chamber
Autor/es:
ANDREA P. RODRIGUEZ; HIDETSUGU TSUJIGIWA; HITOSHI NAGATSUKA; ICHIKAWA K; MINOSHINI A; MISSANA L; QIN CL; NAGAI NURIYUKI
Revista:
Journal of Hard Tissue Biology
Editorial:
Takayama Press System Co.
Referencias:
Lugar: Tokyo; Año: 2005 vol. 14 p. 294 - 295
Resumen:
Preliminary analysis of cells before using them in tissue engineering is mandatory. Thus, to clarify the behavior of cells in an appropriate experimental model, we evaluated the characteristic of MDPC-23 cells and LUSA/A1 cells in vitro and in vivo seeded in diffusion chamber. Our results indicated that KUSA/A1 cells differentiated into osteoblast-like cells and induced bone tissue inside the chamber. Whereas, MDPC-23 dells were odontoblast-like cells but with low ability to induce dentin formation. This study suggests that MDPC-23 cells are special cells, which possess morphological and functional character of odontoblast-like cells, expressing DSPP only in vivo with capacity to induce mineralized dentin matrix.