INVESTIGADORES
FERNANDEZ Alicia Silvina
congresos y reuniones científicas
Título:
Prevalence of anthelmintic resistance in cattle nematodes and risk factors: A systematic review-meta-analysis approach.
Autor/es:
MEDEROS, AMÉRICA; CARRACELAS, BEATRIZ; MINHO, ALESSANDRO; FERNÁNDEZ, ALICIA SILVINA; SÁNCHEZ, JAVIER
Lugar:
Perth
Reunión:
Conferencia; 24th International Conference of the World Association for the Advancement of Veterinary Parasitology; 2013
Institución organizadora:
The Australian Society for Parasitology
Resumen:
The main goal of this study was to identify the potential risk factors (RF) associated with the prevalence of anthelmintic resistance (AR) of bovine gastrointestinal nematodes. A systematic review (SR) and metaanalysis (MA) was conducted to collate, assess and summarize the scientific literature. This methodology has been used in order to minimize biases, obtain more precise estimates and identify sources of variability that could explain the differences in the prevalence of anthelmintic resistance. A systematic review protocol was designed a priori, validated and tested. A search algorithm was applied to four electronic databases and one level of relevance screening was conducted by two reviewers. Quality assessment and data extraction were performed in one single step. A random effects MA was performed to summarize the evidence of AR prevalence for each drug evaluated and RF were assessed qualitatively. Twenty three studies (5 cross-sectional, 9 prevalence surveys and 9 field trials) from 15 countries were included in this review. The overall percentage of farms with AR in at least one drug was 82.1% (95% CI=70.5 to 93.7), and the between study heterogeneity was high (I2=94.8%). The sub-group analysis showed the following prevalence by drug class: ivermectin 77.0%; moxidectin 74.2%; benzimidazole 44.3% and levamisole 35.0%. The main nematode genera involved in the AR cases were Cooperia spp., Ostertagia spp., Haemonchus sp., Trichostrongylus spp. and Oesophagostomum spp. RF were assessed from 5 studies. One reported significant association for treatment frequency (p