Modeling the electrical activity in myelinated nerve fibers: Towards the electrophysiological validation of neuronal bridges

DE MARCO NM; SOLETTA, J.H.; GOY CB; ALBARRACIN ANA LIA; FELICE CJ; FARFÁN FD

Congreso; SABI 2020 - CONGRESO ARGENTINO DE BIOINGENIERIA; 2020

When severe injuries occur in the Central or Peripheric Nervous Tissue, this often triggers events thatpermanently damage the neurological function, which leads to a reduction in the patient?s quality of life. The use of bio-materialsscaffolding to create bridges that re-establish the lost connections are promising, but currently, have limited applicability; andelectrophysiological and biological validations demand considerable time, so it is still a field being explored by many investigatorsaround the world. In this paper a simplified empirical model is proposed to describe an action potential generation an conductionthrough myelinic fibers. The model's electrophysiological validation was performed through qualitative analysis in threeexperimental situations that call for action potential: a) sciatic nerve in frog, b) giant lateral axons and giant medial axon inearthworm, and c) infraorbital nerve in rats. Results evidence the proposed empirical model's great versatility to the differentevoked action potentials. The proposed model could become a valuable tool to determine the percentage of functionallyconnected fibers through neural bridges made of various materia