Muscular activity decline in a Parkinson's disease animal model

ALBARRACIN, AL; FARFÁN, F.D.; TERUYA PY; PIZÁ AG; LUCIANNA FA; SOLETTA JH

Cordoba

Congreso; XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2019

SAN

Parkinson?s disease diagnosis is currently based on characteristic motor dysfunctions induced by the dopaminergic neurons depletion in the substantia nigra pars compacta (SNpc). The most common Parkinson?s disease animal model induces massive nigrostriatal degeneration by intracerebral infusion of 6-hydroxydopamine (6-OHDA). Using chronic implanted EMG electrodes in a hindlimb muscle of freely moving rats, we evaluate the effect of the PD neurotoxic model in the muscular activity over time. Power spectrum density (PSD) from each EMG signals obtained from animals with different time post-surgery were analyzed. Our results show that as the time post-lesion increases both frequency parameters decrease Changes in the PDS have been detected since 3 weeks from the lesion surgery. Those changes due to the time post-injury are represented by PSDs compressed to low frequencies and defined a transition from a symmetrical to an asymmetrical morphology