Análisis de oscilaciones corticales gamma sincronizadas con la marcha: Estudio preliminar en un modelo animal de Enfermedad de Parkinson

SORIA JC; TERUYA PY; PIZÁ AG; FARFÁN FD; ALBARRACIN, AL

Congreso; XXI Congreso Argentino de Bioingenieria; 2017

Gait disorders are caused by many neurologicaland non-neurological diseases and often reflect a broad range ofdysfunctions of the central and peripheral nervous systems.Parkinson?s disease (PD) is characterized by motor dysfunctionsand gait disturbance that include changes in spatiotemporalfeatures of locomotion such as reduced overall velocity, decreasedarm swing, reduced stride length, and increased duration of thestance phase. In this preliminary study we have exploreddynamics aspects of the gait in a 6-OHDA rat model of PD andhave quantified the gait parameters changes and its correlationwith electrical parameters of movement?s cortical control. Highspeeddigital cameras have been used to image the side of ratswalking on a transparent and circular treadmill. Images of thehindlimb step cycle were digitalized and quantified to becorrelated with the cortical activity recorded from the hindlimbmotor area. The electrocorticographic signals were correlatedwith gait analysis data in order to study qualitative andquantitative aspects of motor control. Preliminary resultsshowed remarkable differences between the maximum angle ofmovement and the phase of the gait cycle in which this angle isreached. Synchronizations were found between movements of thegait cycle and activations in the gamma band in the primarymotor cortex; the gamma activations were reduced on theinjured side. In the animal control, the onsets in the gammawaves occur between 20-40% and between 60-80% of the gaitcycle, whereas in the injured rats only occurs between 20-40%.This experimental protocol allows the complete study of the stepcycle and correlates it with changes