Preliminar Electrocorticographic Study of Normal and Abnormal Gait in rats

COLETTI MA; TERUYA PY; ALBARRACÍN AL; FARFÁN FD; FELICE CJ

Cordoba

Congreso; XXVIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2013

Electrocorticography (ECoG) is one of the main tools for the analysis of electrophysiological manifestations in the brain, evoked by sensory and motor activities. This work studies the electrocortical manifestations evoked by the normal and abnormal rat?s gait. Adult Wistar female rats were used and performed to chronic nichrome electrode implants in the primary motor cortex (one in each hemisphere). Electrodes were implanted in specific locations of the primary motor cortex corresponding to the maximum sensitivity area for a given motor evoked response. Locations were determined by a topographic mapping technique with intracortical stimulation (ICMS). It was designed a sliding platform in which the normal gait of the rats was carried out. An abnormal gait was achieved anesthetizing the left hindlimb of the rat. ECoG records were obtained through a BIOPAC system at 500Hz sampling rate and bandwidth of 0.05Hz to 250Hz. Subsequently, a time-frecuency analysis was performed to the ECoG records in both experimental situations. Results show temporal and spectral patterns evoked by the normal gait, which significantly changed during abnormal gait