Moderate running protects against pancreas damage in chronic cola drinking rats

OTERO-LOSADA M.; GONZALEZ J; MÜLLER A; OTTAVIANO G; CAO G; AMBROSIO G.; MILEI J

Congreso; 26th European Meeting on Hypertension and Cardiovascular Protection; 2016

Nearly for ten years, we have been studying the variety of physiological andmorphological alterations found after chronic ingestion of cola beverages in bothgenetically modified mice and normal rats. In healthy rats, chronic cola drinking inducesbiochemical and echocardiographic changes, namely, dyslipidemia, hyperglycemia,cardiac remodeling with left ventricle hypertrophy and increased cardiac output. Cola drinking for 6 months, induces hyperglycemia, hypertriglyceridemia, mild overweightand insulin resistance, and affects endocrine pancreas morphology in otherwise healthyrats.This study evaluates whether the daily practice of an aerobic exercise routine mightprotect from endocrine pancreas damage induced by chronic cola drinking in rats. We show an experimental model combining the systematic practice of an aerobic exercise with cola-drinking, that mimicks a frequent association in human life-style at present.