Pleiotropic effect of antihypertensive pharmacological treatments in spontaneously hypertensive rats

GÓMEZ LLAMBÍ H; CAO G; G OTTAVIANO; MULLER A; GELPI RJ; M OTERO LOSADA; J MILEI

Congreso; 25 th European Meeting on Hypertension and Cardiovascular Protection; 2015; 2015

Losartan treatment increased the number of capillaries and cardiomyocytes of normal size, reduced interstitial volume and myocyte-to-capillary distance in LV. Rosuvastatin treatment increased the number of capillaries in both ventricles. These findings and inhibition of LVH development with normalization of basal inotropism and beta adrenergic response as shown in other presentation in this Congress, point out that Losartan might be the most effective antihypertensive of those presently examined. It follows that activation of angiotensin II receptors might be a key step in LVH development with decline in beta adrenergic response in hypertension. The presence of LVH or cardiac failure was associated with expression of thioredoxins only in some cases suggesting that oxidative stress may not be determinant in LVH development.