Overexpression of thioredoxins after antihypertensive pharmacological treatments is dissociated from cardiac hypertrophy inhibition and restored contractility in hypertensive rats

H GÓMEZ LLAMBÍ; DONATTI S; B BUCHOLZ; CAO G; G OTTAVIANO; MULLER A; GELPI RJ; M OTERO LOSADA; J MILEI

Congreso; 25 th European Meeting on Hypertension and Cardiovascular Protection; 2015; 2015

Treatment with L, H and Cprevented the development of LVH. Losartan normalized the contractile responseto isoproterenol in SHR. Development of LVH with decline in the inotropicresponse to beta-adrenergic stimulation in hypertension may involve additionalfactors as well. High expression of thioredoxins observed afterantihypertensive treatments suggests a subsidiary benefit by enhancing antioxidant defense against oxidative stress in hypertension