PERSONAL DE APOYO
CAO Gabriel Fernando
artículos
Título:
Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas
Autor/es:
TOBLLI JE1, CAO G, OLIVERI L, ANGEROSA M.
Revista:
Inflammation & allergy drug targets
Editorial:
Bentham Science Publishers
Referencias:
Lugar: San Francisco, CA; Año: 2013 p. 190 - 198
ISSN:
1871-5281
Resumen:
Although oral iron preparations are widely prescribed to prevent and to
treat iron deficiency anemia in pregnancy, comparative data on their
effects to the mother, fetus and placenta are limited. In this study,
the effects of oral iron polymaltose complex (IPC), ferrous fumarate
(FF) and ferrous sulfate (FS) were compared in anemic pregnant rats,
their fetuses and placentas. Hematological variables and oxidative
stress markers in the liver, heart and kidneys of the dams and fetuses
as well as the markers for oxidative stress, inflammation and hypoxia in
placentas were assessed. Pregnancy outcome was measured by number of
fetuses, and by neonate and placental weight. All therapies were
comparably effective in correcting anemia. FS and FF, but not IPC,
resulted in liver damage in dams and oxidative stress in dams, fetuses
and placentas. FS group presented the highest catalase and GPx levels in
dams, fetuses and placentas. IPC, but not FF or FS, restored normal
TNF-α and IL6 expression levels in placentas whereas FS-treated animals
presented the highest cytokine levels, suggesting a local inflammatory
reaction. Anemia-induced high levels of HIF-1α were partially lowered by
IPC and FF but further elevated by FS. Most of the negative effects
associated with IDA were resolved by IPC treatment. Especially FS
treatment was found to elicit hepatic damage in the dams, oxidative
stress in the dams, fetuses and placenta as well as inflammation and
high levels of HIF-1α in the placenta. Pregnancy outcome of FFand
FS-treated animals was worse than that of IPC-treated animals.