INVESTIGADORES
DRUCAROFF Lucas Javier
artículos
Título:
Hemispheric specialization of mood processing is abnormal in patients with schizophrenia
Autor/es:
DRUCAROFF, LUCAS J.; COSTANZO, ELSA Y.; CASTRO, MARIANA N.; ORTIZ-VILLAFAÑE, MANUEL; WAINSZTEIN, AGUSTINA E.; ABULAFIA, CAROLINA; DUARTE-ABRITTA, BÁRBARA; VILLARREAL, MIRTA F.; GUINJOAN, SALVADOR M.
Revista:
SCHIZOPHRENIA RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2016 vol. 176 p. 452 - 453
ISSN:
0920-9964
Resumen:
Background Abnormalities of brain lateralisation are ubiquitous in structural and functional studies of patients with schizophrenia. There is evidence that emotion processing is lateralised in healthy subjects but this variable has not been studied in schizophrenia.Method We performed fMRI during phonological fluency and sadness induction tasks in 15 patients with chronic schizophrenia and 20 matched healthy individuals.Results Healthy individuals exhibited a left lateralisation of language-related brain activity which was not present in patients with schizophrenia. Right-hemisphere structures were predominantly activated during sadness induction in controls but not in patients. However, rightward lateralisation of sadness-induced activity was present in patients when the insular cortex was probed specifically. The degrees of lateralisation of language and sadness-induced brain activities were related in controls, but not in patients. In the latter grouppatients, lateralisation of sadness-induced activity in the amygdalae was inversely correlated with thalamic lateralisation during the same condition. Language lateralisation and degree of self-reported dexterity were related in controls although contrary to prediction, more intense right handedness was inversely related with to left hemisphere activation during thea fluency task. No such relationship was observed in patients.Conclusions The present results support the hypothesis that abnormalities in the development of brain lateralisation are widespread in schizophrenia and involve circuits implicated in mood regulation in addition to those subserving language and motor function.