INVESTIGADORES
RONDA Ana Carolina
artículos
Título:
1a ,25(OH)2-Vitamin D3 and 17b-Estradiol: Two Steroid Partners Acting in Skeletal Muscle
Autor/es:
RICARDO BOLAND; CLAUDIA BUITRAGO; LORENA MILANESI; ANA CAROLINA RONDA; ANDREA VASCONSUELO
Revista:
MEDICINAL CHEMISTRY: Immunology, Endocrinology and Metabolic Agents
Editorial:
Bentham Science Publishers
Referencias:
Año: 2009 vol. 9 p. 159 - 168
ISSN:
1871-5222
Resumen:
1a,25(OH)2-vitamin D3 and 17b-estradiol regulate skeletal muscle cell proliferation, differentiation, apoptosis and contractility through receptor-mediated transcriptional and non-genomic mechanisms. This review focuses on recent advances on signal transduction pathways activated by both steroid hormones. Data are given on the participation of the VDR and ERs (a and b) in activation of MAPKs in muscle cells. Likewise, we describe novel evidence supporting non-classical localizations of the VDR in the plasma membrane and ER b in mitochondria. 1a,25(OH)2D3 promotes DNA synthesis in skeletal muscle cells implicating c-Src/ERK1/2, whereas 17b-estradiol inhibits apoptosis through ERK2 and p38 MAPKs.This study provides basis for the understanding of vitamin D- and estrogen-dependent myopathies.