INVESTIGADORES
RONDA Ana Carolina
artículos
Título:
17beta-Estradiol signaling in skeletal muscle cells and its relationship to apoptosis
Autor/es:
BOLAND RICARDO; VASCONSUELO ANDREA; MILANESI LORENA; RONDA ANA CAROLINA; ANA RUSSO DE BOLAND
Revista:
STEROIDS
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 73 p. 859 - 863
ISSN:
0039-128X
Resumen:
17beta-Estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERalpha and beta. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the level of mitochondria, whereas ERalpha and ERbeta mediate the activation of Akt to the same extent, suggesting differential involvement of ER isoforms depending on the step of the apoptotic/survival pathway involved. The myopathies associated to estrogen deficit states may be related to the mechanisms by which estrogen regulates apoptosis.