INVESTIGADORES
OLEA Fernanda Daniela
artículos
Título:
High-dose erythropoietin has no long-term protective effects in sheep with reperfused myocardial infarction
Autor/es:
OLEA FD; VERA JANAVEL G; DE LORENZI A; CUNIBERTI L; YANNARELLI G; CABEZA MECKERT P; CEARRAS M; LAGUENS R; CROTTOGINI A
Revista:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Editorial:
Lippincott Williams & Wilkins
Referencias:
Lugar: Baltimore, MD; Año: 2006 vol. 47 p. 736 - 741
ISSN:
0160-2446
Resumen:
High-dose erythropoietin has been claimed to be cardioprotective in experimental acute myocardial infarction. In large mammals, however, results are controversial and long-term follow-up data are lacking. We thus assessed the long-term effects of high-dose erythropoietin on left ventricular infarct size and function in an ovine model of reperfused myocardial infarction. After 90 minutes of coronary occlusion followed by reperfusion, sheep received recombinant human erythropoietin (rhEPO) 3000 units/kg on 3 consecutive days (rhEPO group, n=7) or vehicle (placebo group, n=6). Ten weeks later, ventricular function was assessed by echocardiography and catheterization. Infarct size, evaluated as percent fibrotic myocardium (morphometry) and by hydroxyproline quantification, was similar in both groups (morphometry: rhEPO: 22.1 +/- 5.5%, placebo: 18.1 +/- 3.3%, P not significant; hydroxyproline: rhEPO: 6.6 +/- 1.3 microg/mg wet weight, placebo: 7.1 +/- 0.9 microg/mg, P not significant). Ventricular function was diminished in the rhEPO group, as indicated by lower septal wall thickening at the infarct border zone (rhEPO: -1.9 +/- 16.4%, placebo: 20.5 +/- 17%, P