INVESTIGADORES
D`ALESSIO Luciana
congresos y reuniones científicas
Título:
Risk Factors for Psychotic disorders in patients with temporal lobe epilepsy.
Autor/es:
D`ALESSIO L, GIAGANTE B, IBARRA V, PAPPAYANNIS C, ODDO S, SOLIS P, SILVA W, DONNOLI V,CONSALVO D, KOCHEN S.
Lugar:
Helsinsky
Reunión:
Congreso; European Congress of epileptology; 2006
Institución organizadora:
Liga Internacional contra la Epilepsia
Resumen:
Risk Factors for Psychotic disorders in patients with temporal lobe epilepsy. Porpose Temporal lobe epileptic patients are at higher risk for acute and chronic psychotic disorders but the etiology of this association is not clearly defined. The aim of this study was to determine risk factor for psychosis in temporal lobe epileptic patients. Methods  118 patients with neurological, neurophysiologic and neuroimaging criteria for temporal lobe epilepsy were included.Two groups of patients were determined: 61 patients (52%) with psychotic disorders codified in Axis I of DSM IV were compared with 57 patients (48%) without psychotic disorders. Psychotic Disorders were defined by DSM IV criteria (SCDI I and II), and postictal and/or interictal psychosis were additionally diagnosed. Sex, age, age of epilepsy onset and epilepsy time duration, febrile convulsions, generalized seizures, status history, presence of unilateral and bilateral hippocampal sclerosis, and laterality of epileptic discharges diagnosed by video-eeg Results More frequent DSM IV psychotic disorders diagnosed were Brief psychotic disorders (39%), schizophrenia (24%) and schizophreniform disorder (13%). Postictal psychotic episodes were reported in 29 patients with DSM IV psychotic disorders (47%). Topiramato in four patients and vigabatrine in one patient induced interictal psychosis (8%). Conclusions Age of epilepsy onset was earlier and epilepsy time duration longer, in psychotic group, compared with the control group: p = 0, 04 / p = 0,017. Status epilepticus history, and bilateral hippocampal sclerosis was more prevalent in psychotic patients p= 0, 02/0, In this study longer evolution, status epilepticus history, and bilateral hippocampal sclerosis, risk factors for epilepsy severity, were significatively more frequent in patients with psychotic disorders.