INVESTIGADORES
D`ALESSIO Luciana
artículos
Título:
Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis.
Autor/es:
MARCELO ANDRÉS KAUFFMAN, DAMIÁN CONSALVO, DOLORES GONZALEZ-MORÓN, FLORENCIA AGUIRRE, LUCIANA D`ALESSIO, SILVIA KOCHEN.
Revista:
EPILEPSY RESEARCH
Editorial:
Elsevier
Referencias:
Lugar: The Netherlands; Año: 2009 vol. 85 p. 231 - 234
ISSN:
0920-1211
Resumen:
We performed a molecular epidemiology study in a population of 105 mesial temporal
lobe epilepsy with hippocampal sclerosis (MTE-HS) patients in order to investigate the role
of a polymorphism in the serotonin transporter gene (SLC6A4) in the prediction of antiepileptic
drug (AED) treatment response. Homozygous carriers of the 12-repeat allele had an almost
fourfold increase in risk for a MTE-HS not responding to medical treatment (OR 3.88; CI 95%
1.4010.7; p = 0.006) compared to carriers of the 10-repeat allele. Therefore, a polymorphism
of SLC6A4 might be a genetic marker of pharmacoresistance in MTE-HS patients.p = 0.006) compared to carriers of the 10-repeat allele. Therefore, a polymorphism
of SLC6A4 might be a genetic marker of pharmacoresistance in MTE-HS patients.