INVESTIGADORES
SZPILBARG Natalia
congresos y reuniones científicas
Título:
Placental aquaporin-3: a potential molecular target for aspirin in the treatment of preeclampsia
Autor/es:
REYNOSO MARIANO; SAR JUAN SEBASTIÁN; SZPILBARG NATALIA; DAMIANO ALICIA ERMELINDA
Lugar:
Maceió
Reunión:
Congreso; X SLIMP MEETING; 2024
Institución organizadora:
Sociedad Latinoamericana de Interacción Materno-Fetal y Placenta ? Latin American Society for Materno Fetal Interaction and Placenta
Resumen:
OBJECTIVE Aquaporin-3 (AQP3) protein expression is significantly reduced in preeclamptic placentas. This protein is involved in the migration and differentiation of the extravillous trophoblasts, suggesting that it is crucial in early stages of placental development. Drugs that modulate its expression may improve placentation. Low-dose aspirin (LDA) before the 16th week of gestation proved to be effective in preventing early preeclampsia, acting by a mechanism unrelated to cyclooxygenase inhibition. We aimed to study the effect of LDA on AQP3 expression in placenta samples from normal and preeclamptic gestations. METHODS This study was approved by the Ethics Committee of FFyB-UBA (RES.CD-2023-836). Forty-two normal and twenty-one placentas with a diagnosis of preeclampsia were collected post-cesarean section and categorized according to the intake of LDA during pregnancy. Histological examination of the placentas was performed to evaluate the vessel caliber and the % of syncytial nuclear aggregates (SNA). Placental AQP3 expression was assessed by Western blot. RESULTS Aspirin treatment during pregnancy increased AQP3 expression (n=13; p