INVESTIGADORES
REY Osvaldo
artículos
Título:
Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.
Autor/es:
CHIU R, REY O, ZHENG JQ, TWISS JL, SONG J, PANG S, YOKOYAMA KK.
Revista:
CELLULAR AND MOLECULAR NEUROBIOLOGY.
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Año: 2003 p. 929 - 943
ISSN:
0272-4340
Resumen:
The retinoblastoma susceptibility gene product, p105Rb (RB), is an
important regulator in the control of cell proliferation,
differentiation, and apoptosis. Several cellular factors that complex
with RB and exert their cellular regulatory functions have been
identified, such as the RB:cyclophilin A (CypA) complex. 2. CypA is a
cytoplasmic immunophilin and known for its involvement in T-cell
differentiation and proliferation. Although CypA has a pivotal role in
the immune response, its function in other signaling pathways is
largely unknown. 3. In this study, we used a model of neuronal
differentiation to demonstrate that the nuclear translocation of CypA,
the appearance of hypophosphorylated RB and the enhancement of RB: CypA
complex formation correlates with retinoic acid induced neuronal
differentiation. 4. Inhibition of CypA expression results in repression
of both the hypophosphorylated RB and the neuron-specific
differentiation marker, class III beta tubulin. 5. The evidence of
enriched CypA and colocalization of RB with CypA in the nucleus of
primary adult sensory neurons substantiated the important event of
RB-mediated neuronal differentiation of p19 EC cells.