INVESTIGADORES
REY Osvaldo
artículos
Título:
HIV-1 Gag protein associates with F-actin present in microfilaments
Autor/es:
REY O, CANON J, KROGSTAD P.
Revista:
VIROLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1996 p. 530 - 534
ISSN:
0042-6822
Resumen:
Several studies have provided evidence that the cellular cytoskeleton
may be involved in the assembly and budding of retroviruses. In
fractionation studies of HIV-1-infected CEM cells, the majority of the
unprocessed Gag polyprotein cofractionated with the cellular
cytoskeleton. In vivo and in vitro analyses of this interaction
indicated that the unprocessed Gag polyprotein is capable of
association with polymerized actin (F-actin). Binding of Gag to F-actin
may be involved in the assembly or budding of HIV-1.
