INVESTIGADORES
DITAMO Yanina
artículos
Título:
Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis
Autor/es:
LEE, CHIH-YING; BISIG, C. GASTON; CONRAD, MICHAEL M.; DITAMO, YANINA; PREVIATO DE ALMEIDA, LUCIANA; DRESSER, MICHAEL E.; PEZZA, ROBERTO J.
Revista:
CURRENT BIOLOGY
Editorial:
CELL PRESS
Referencias:
Año: 2020 vol. 30 p. 1207 - 1216
ISSN:
0960-9822
Resumen:
Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid prophase movements are unknown, and the mechanism underlying rapid prophase movements remains poorly understood. We identified S. cerevisiae Mps2 as the outer nuclear membrane protein that connects the LINC complex with the cytoskeleton. We also demonstrate that the motor Myo2 works together with Mps2 to couple the telomeres to the actin cytoskeleton. Further, we show that Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a regulator of the Mps2-Myo2 interaction. We propose a model in which the newly identified functions of Mps2 and Myo2 cooperate with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton.