INVESTIGADORES
PEREZ LLORET Santiago
congresos y reuniones científicas
Título:
Decision-making in Parkinson's disease patients with and without pathological gambling
Lugar:
Paris, Francia
Reunión:
Congreso; Congreso Internacional de Movimientos Anormales; 2009
Resumen:
Objective: To analyze decision-making processes in Parkinson's disease (PD) patientswith and without pathological gambling (PG).Background: Pathological gambling in PD patients is a frequent impulse controldisorder associated mainly with dopamine replacement therapy. Decision-makingimpairments have been described independently in PG and PD, yet decision-makingprocesses in PD patients with PG has seldom been studied.Methods: Seven PD patients with PG (defined by DSM-IV, South Oaks Gambling Screenand the Minnesota Impulsive Interview) and 7 age-, sex-, education- and diseaseseverity-matched PD patients without PG or any other impulse control disorder wereenrolled in the study. All patients were assessed with a comprehensive neuropsychiatricand cognitive evaluation, including tasks used to assess decision-making abilities underambiguous or risky situations, like the Iowa Gambling Task (IGT), the Game of DiceAbstract Preview http://www.call4abstracts.com/mds/preview.php?abs=550239&rtn=sl...1 de 2 10/01/2009 05:28 p.m.Task and the Investment Task.Results: PD patients with PG were younger at PD onset (52.0 5.6 vs 59.4 4.5,p<.026). PG patients obtained a lower score than non-PG patients in the IGT (-20.312.4 vs. 3.7 6.6, p=.001) and in the Social Behavior Questionnaire (3.1 0.5 vs 4.1 0.5,p=.009). No significant differences between groups were found for the GDT and theInvestment Task.Conclusions: Low performance in decision-making under ambiguity and abnormalsocial behavior distinguished PD patients with PG from those without this disorder.Dopamine replacement therapy may induce dysfunction of the ventromedial prefrontalcortex and amygdala-ventral striatum system, thus increasing the risk for developingPG.