Prevalence, impact, and factors associated with excessive buccal saliva in the COPARK database.

SANTIAGO PEREZ LLORET; OLIVIER RASCOL

Congreso; 24th International Congress of Parkinson?s Disease and Movement Disorders; 2020

Objectives: To describe the prevalence of sialorrhea and drooling in Parkinson?s Disease (PD) patients of the COPARK study, to find factors associated to these conditions, and to assess its impact on Health-related Quality of life (HRQoL).Background: Sialorrhea and drooling are bothersome features of PD.Methods: We studied 671 ambulatory non-demented PD patients and 177 sex- and age-matched outpatients from the COPARK database. Patients and controls were examined by a neurologist using a standardized and structured interview. For this study, we defined: a) ?sialorrhea? as an excess of saliva in the buccal cavity (i.e. UPDRS item #6 ?Salivation?= 1 or 2); b) ?drooling? as saliva excess leading to drooling, potentially requiring treatment (i.e. UPDRS item #6= 3 or 4). These definitions were applied to ?ON? and ?OFF? conditions. SCOPA-Aut item #2 ?drooling? score was also available for a subgroup of PD and controls. HRQoL was assessed by the PDQ-39 and SF-36 scales. We also analyzed 24-months follow-up data, which was only available for 401/683 PD patients (59%).Results: In PD, sialorrhea and drooling were present in 237 out of 671 (35.3%) and 17/671 (2.5%) cases in the ?ON? condition. UPDRS item #6 score was significantly worse in the ?OFF? condition as compared to the ?ON? condition (0.87±0.07 vs 0.53±0.05, n=229, p 26 (2.5,1.7-3.5), and dysphagia (2.5,1.6-3.7). Additionally, ordinal logistic regression identified social support and communication from the PDQ-39 as the only HRQoL subdomains significantly associated with sialorrhea and drooling. UPDRS #6 scores in the ?ON? condition increased significantly after 24-months (p