INVESTIGADORES
PEREZ LLORET Santiago
congresos y reuniones científicas
Título:
Comparison of Parkinson?s disease olfactory identification patterns among patients from different countries
Autor/es:
PATRICIO MILLAR VERNETTI; SANTIAGO PÉREZ LLORET
Reunión:
Congreso; 18th International Congress of Parkinson's Disease and Movement Disorders; 2014
Resumen:
 BACKGROUNDOlfactory function assessment is an important screening tool and also may differentiate PD patients from other parkinsonisms including non degenerative ones. Several authors in different countries have reported various sets of odors that best differentiate between these conditions. It is debated if distinctive patterns of ?restrictive? or ?selective? hyposmia in PD may be affected by cultural aspects.OBJECTIVETo compare the olfactory identification function in Parkinson?s disease (PD) across different countries. METHODSPopulation and evaluationSniffin? Sticks identification task (SSI) results were compared between 112 PD patients from Argentina (ARG) and previously reported data of PD patients from Brazil (BRZL; 106 patients), the Netherlands (404 patients), Germany (GER; 40 patients), China (110 patients) and Sri Lanka (SRL; 89 patients). Studies from BRZL, SRL and China included current smokers and patients with history of tobacco use, which did not affect SSI score. SSI consists of 16 odors delivered through felt tip markers, namely: orange, lemon, banana, pineapple, apple, cinnamon, clove, anise, liquorice, coffee, mint, roses, garlic, fish, leather and turpentine. Statistical analysisChi-square with Bonferroni adjustment was performed. Categorical principal component analysis (CATPCA) was conducted to find components reflecting groups of odors similarly perceived across subjects. A total score for each component was calculated as the sum of positive answers and compared across countries by one-way ANOVA followed by Tukey?s HSD post-hoc. RESULTSCATPCA analysis found 2 components (C1: apple, cinnamon, liquorice, lemon, anise, turpentine and pineapple; C2: roses, coffee, leather, mint, orange, banana, garlic, clove and fish). Only C2 total score significantly varied across countries (p<0.05). GER and SRL populations seemed the most and least sensitive to these odors, respectively. ARG and BRZL showed less sensitivity for orange, leather and clove odors, and SRL seemed less sensitive for banana. There were no differences across countries in sensitivities to cinnamon, lemon, garlic or pineapple. CONCLUSIONSWe found different sensitivities to odors across different countries, which could depend on a cultural aspect.CONCLUSIONSWe found different sensitivities to odors across different countries, which could depend on a cultural aspect.METHODSPopulation and evaluationSniffin? Sticks identification task (SSI) results were compared between 112 PD patients from Argentina (ARG) and previously reported data of PD patients from Brazil (BRZL; 106 patients), the Netherlands (404 patients), Germany (GER; 40 patients), China (110 patients) and Sri Lanka (SRL; 89 patients). Studies from BRZL, SRL and China included current smokers and patients with history of tobacco use, which did not affect SSI score. SSI consists of 16 odors delivered through felt tip markers, namely: orange, lemon, banana, pineapple, apple, cinnamon, clove, anise, liquorice, coffee, mint, roses, garlic, fish, leather and turpentine. Statistical analysisChi-square with Bonferroni adjustment was performed. Categorical principal component analysis (CATPCA) was conducted to find components reflecting groups of odors similarly perceived across subjects. A total score for each component was calculated as the sum of positive answers and compared across countries by one-way ANOVA followed by Tukey?s HSD post-hoc. RESULTSCATPCA analysis found 2 components (C1: apple, cinnamon, liquorice, lemon, anise, turpentine and pineapple; C2: roses, coffee, leather, mint, orange, banana, garlic, clove and fish). Only C2 total score significantly varied across countries (p<0.05). GER and SRL populations seemed the most and least sensitive to these odors, respectively. ARG and BRZL showed less sensitivity for orange, leather and clove odors, and SRL seemed less sensitive for banana. There were no differences across countries in sensitivities to cinnamon, lemon, garlic or pineapple. CONCLUSIONSWe found different sensitivities to odors across different countries, which could depend on a cultural aspect.CONCLUSIONSWe found different sensitivities to odors across different countries, which could depend on a cultural aspect.