INVESTIGADORES
PEREZ LLORET Santiago
congresos y reuniones científicas
Título:
Medication use in patients with multiple system atrophy (MSA) or Parkinson?s disease (PD) compared to a group of patients consulting a general practitioner (GP).
Autor/es:
SANTIAGO PÉREZ LLORET; MARIA VERÓNICA REY; A. PAVY-LE TRAON; W. MEISSNER; F. ORY-MAGNE; C. BREFEL-COURBON; L. RATTI; N. FABRE; F. TISON; O. RASCOL
Reunión:
Congreso; 16th International Congress of Parkinson?s Disease and Movement Disorders; 2012
Resumen:
Objective: To compare drug utilization between MSA, Parkinson´s disease (PD) patients or unselected patients consulting a general practitioner (GP). patients consulting a general practitioner (GP). To compare drug utilization between MSA, Parkinson´s disease (PD) patients or unselected patients consulting a general practitioner (GP). Background: Multiple system atrophy (MSA) is a neurodegenerative disorder in which medication use hasMultiple system atrophy (MSA) is a neurodegenerative disorder in which medication use has been poorly studied. Methods: 147 MSA patients (according to Gilman criteria) were assessed at the MSA reference Center between 2008 and 2011. 653 PD patients (according to UKPDSBB criteria) and 98 patients assisting to a GP for reasons not related to PD or MSA were recruited from the same geographical area. Data were analyzed by chi-square test followed by pairwise comparisons by bonferroni-adjusted z-test for proportions. between 2008 and 2011. 653 PD patients (according to UKPDSBB criteria) and 98 patients assisting to a GP for reasons not related to PD or MSA were recruited from the same geographical area. Data were analyzed by chi-square test followed by pairwise comparisons by bonferroni-adjusted z-test for proportions. 147 MSA patients (according to Gilman criteria) were assessed at the MSA reference Center between 2008 and 2011. 653 PD patients (according to UKPDSBB criteria) and 98 patients assisting to a GP for reasons not related to PD or MSA were recruited from the same geographical area. Data were analyzed by chi-square test followed by pairwise comparisons by bonferroni-adjusted z-test for proportions. Results: MSA patients were younger as compared to PD or GP patients (65±1 vs 68±1 or 71±1 years p<0.001). Proportion of males was similar in the 3 groups (MSA: 50% vs PD: 49% or 46%, p=0.9). MSA patients were more frequently exposed to drugs for bowel disorders (MSA: 19% vs PD: 6% or GP: 10% p<0.001), to urinary antispasmodics (MSA: 18% vs PD: 2% or GP: 1% p<0.001) to drugs used for orthostatic hypotension such as midodrine or fludrocortisone (MSA: 42% vs PD: 3% vs GP: 0%, p<0.001) ot to antihypertensives (MSA: 22% vs PD: 40% vs GP: 58% p<0.001). MSA patients were less frequently on antiparkinsonian as compared to PD (73% vs 88% p<0.05). Finally, MSA patients were more frequently on antidepressants (MSA: 48% vs PD: 18% or GP: 10% p<0.001). p<0.001). Proportion of males was similar in the 3 groups (MSA: 50% vs PD: 49% or 46%, p=0.9). MSA patients were more frequently exposed to drugs for bowel disorders (MSA: 19% vs PD: 6% or GP: 10% p<0.001), to urinary antispasmodics (MSA: 18% vs PD: 2% or GP: 1% p<0.001) to drugs used for orthostatic hypotension such as midodrine or fludrocortisone (MSA: 42% vs PD: 3% vs GP: 0%, p<0.001) ot to antihypertensives (MSA: 22% vs PD: 40% vs GP: 58% p<0.001). MSA patients were less frequently on antiparkinsonian as compared to PD (73% vs 88% p<0.05). Finally, MSA patients were more frequently on antidepressants (MSA: 48% vs PD: 18% or GP: 10% p<0.001). MSA patients were younger as compared to PD or GP patients (65±1 vs 68±1 or 71±1 years p<0.001). Proportion of males was similar in the 3 groups (MSA: 50% vs PD: 49% or 46%, p=0.9). MSA patients were more frequently exposed to drugs for bowel disorders (MSA: 19% vs PD: 6% or GP: 10% p<0.001), to urinary antispasmodics (MSA: 18% vs PD: 2% or GP: 1% p<0.001) to drugs used for orthostatic hypotension such as midodrine or fludrocortisone (MSA: 42% vs PD: 3% vs GP: 0%, p<0.001) ot to antihypertensives (MSA: 22% vs PD: 40% vs GP: 58% p<0.001). MSA patients were less frequently on antiparkinsonian as compared to PD (73% vs 88% p<0.05). Finally, MSA patients were more frequently on antidepressants (MSA: 48% vs PD: 18% or GP: 10% p<0.001). Conclusions: Medication use patterns differed patients with MSA, PD or those assisting to a GP.Medication use patterns differed patients with MSA, PD or those assisting to a GP.