Non-motor symptoms groups in Parkinson’s Disease patients. Results of a pilot, exploratory study.

SANTIAGO PEREZ-LLORET; MALCO ROSSI; MARCELO MERELLO; DANIEL CARDINALI

Parkinson's Disease

SAGE-Hindawi

Año: 2011

2042-0080

Background: A variety of non-motor symptoms (NMS) such asneuropsychiatric symptoms, sleep disturbances, autonomic symptoms, forexample, are a common feature of Parkinson’s Disease (PD).Objective: To explore the presence of NMSs groups as well as to relate themto PD characteristics or its pharmacological treatment.Methods: 71 idiopathic non-demented PD out-patients were recruited. Sleepwas evaluated by the PD Sleep Scale (PDSS). Number of neuropsychiatric,gastrointestinal or urogenital symptoms were obtained from the NMSQuest.Sialorrhea or dysphagia severity was obtained from Unified PD Rating Scaleactivities of daily living section (i.e. items #6 or 7). MADRS depression scalewas also administered.Results: Exploratory factor analysis revealed the presence of 5 factors,explaining 70% of variance. The first factor included PDSS measures of sleepquality, nocturnal restlessness, off-related problems and daytime somnolence;the second factor included measures of nocturia (PDSS) and nocturnal activity;the third one included gastrointestinal and genitourinary symptoms; the forthone included nocturnal psychosis (PDSS), sialorrhea and dysphagia (UPDRS);and the last one included MADRS score as well as neuropsychiatric symptoms.Sleep disorders correlated with presence of wearing-off, nocturia with age > 69years, nocturnal psychosis with levodopa equivalent dose or UPDRS II scorewhile neuropsychiatric symptoms correlated with UPDRS II+III score or nontricyclicantidepressants.Conclusions: These results suggest significant non-motor symptoms grouping.