INVESTIGADORES
BALDO Juan Diego
artículos
Título:
Indolizidine 239Q and Quinolizidine 2751. Major alkaloids in two species of Argentinean Bufonid toad (Melanophryniscus)
Autor/es:
DALY, JOHN; GARRAFFO, MARTIN; SPANDE, T. F.; YEH, H. J. C.; PELTZER, PAOLA; CACIVIO, PEDRO; BALDO, DIEGO; FAIVOVICH JULIÁN
Revista:
TOXICON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2008 vol. 58 p. 858 - 870
ISSN:
0041-0101
Resumen:
Alkaloid profiles in skin of poison frogs/toads (Dendrobatidae, Mantellidae, Bufonidae, and Myobatrachidae) are highly dependent on diet and hence on the nature of habitat. Extracts of the two species of toads (Melanophryniscus klappenbachi and Melanophryniscus cupreuscapularis) from similar habitats in the Corrientes/Chaco Provinces of Argentina have similar profiles of alkaloids, which differ considerably in profiles from other Melanophryniscus species from Brazil, Uruguay and Argentina. Structures of two major alkaloids 239Q (1) and 275I (2) were determined by mass, FTIR, and NMR spectral analysis as 5Z,9Z-3-(1-hydroxybutyl)-5-propylindolizidine and 6Z,10E-4,6-di(pent-4-enyl) quinolizidine, respectively. A third alkaloid, 249F (3), is postulated to be a homopumiliotoxin with an unprecedented conjugated exocyclic diene moiety.