INVESTIGADORES
GUTIERREZ Victoria Soledad
artículos
Título:
Base-Free Direct Synthesis of Alkynylphosphonates from Alkynes and H‑Phosphonates Catalyzed by Cu2O
Autor/es:
MOGLIE YANINA; MASCARÓ EVANGELINA; GUTIERREZ VICTORIA SOLEDAD; ALONSO FRANCISCO; RADIVOY GABRIEL
Revista:
JOURNAL OF ORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2016 vol. 81 p. 1813 - 1818
ISSN:
0022-3263
Resumen:
A simple and mild methodology for the direct synthesis of alkynylphosphonates is presented. The reaction of a variety of terminal alkynes with dialkyl phosphites in the presence Cu2O (14 mol %) led to the formation of the corresponding alkynylphosphonates in good to excellent yields. Reactions are performed under air, in acetonitrile as solvent, and in the absence of base or ligand additives. This new methodology is compatible with the presence of a wide variety of functional groups on the starting alkynes and can be scaled up to a gram scale.
