Comparative analysis of genes under alternative selective strength during primates and murids evolution

SERRA F, ARBIZA L AND H DOPAZO

valencia, España

Jornada; ViII Jornadas de Bioinformática; 2008

red Temática Nacional de Bioinformática

Comparative Analysis of Genes Under Alternative Selective Strenght During Primates and Murids Evolution Serra François, Arbiza Leonardo & Hernán Dopazo Bioinformatics Department. Comparative Genomics Unit Centro de Investigación Príncipe Felipe Valencia, España In a previous work we have defined the number and the functional classes of genes under positive selection and relaxation in human, chimpancee and their common ancestral primate lineage (Arbiza, et al. 2006). As many others authors interested in the action of natural selection in the human genome we've described a few number of genes evolving adaptively, although a higher number were found under weak selection and/or relaxation of selective constraints. Moreover, we concluded that the relative number of genes belonging to different functional classes among different lineages were similar for any of the evolutionary regimes studied. Now we extend this study to all the branches of the phylogenetic tree relating human, chimpancee, macaca, mouse, rat and dog. We search the changes in the selective constraints that have ocurred in different lineages in order to know which are the main differences in adaptive processes that have taken place in the different functional classes of this phylogeny. We will overview all the major differences in selective changes for functional classes of genes changing during lineage evolution. We found that adaptive events occurred in proteins are at expenses of neutral sites and not on those belonging to the class of sites under purifying selection. Arbiza L., Dopazo J. and H. Dopazo. 2006. Positive selection, relaxation and acceleration in the evolution of human and chimp genome. PLoS Comp. Biol. 2(4):e38.