Impact of Low Birth Weight in Vascular Function and Autonomic Regulation of Blood Pressure

PERAL DE BRUNO MARIA; JOO TURONI CLAUDIO; ROSSANA CHAHLA; CHAILA ZULEMA; BAZAN DE CASELLAS C

Puerto Varas

Congreso; XXV Annual Meeting, SLEP.; 2015

SLEP

Objective: Assess the impact of low birth weight (LBW) onheart rate variability (HRV), endothelial function (EF), arterialstiffness (AS) and C-reactive protein (CRP) on vascular functionin children and to determine its relationship with early markers ofcardiometabolic risk.Methods: Children aged 4 to 6 years with LBW (n = 51) or not(control: n = 31) were studied. Waist circumference, height, weight,blood pressure (BP), glucose, insulin, HOMA index, Quicky, lipidprofile and CRP were determined. EF was measured by pulse waveplethysmography evaluating flow-mediated vasodilation. AS wasdetermined by morphology of digital pulse wave. Variability ofheart rate (HR) beat to beat (VFC: standard deviation of the intervalbetween beats); spontaneous variability of heart rate (percentage ofconsecutive beats that differ more than 50%: pNN50) and the productof the maximum HR and SBP (MHRxSBP) were measured.Results: Although waist circumference, height, weight, systolicBP (SBP) and diastolic BP (DBP) were within the 90th percentilein LBW and control; LBW had higher SBP (p < 0.05) and HR (p