Endothelial function in children and young and its relation to cardiovascular risk factors

BAZAN DE CASELLAS C; NEGRETE, ALEJANDRO; JOO TURONI CLAUDIO; SALAS NICOLAS; MARAÑON RODRIGO; SALINAS, JUAN; BRUNO MARIA E.; KARBINER M. SOFÍA; PERAL DE BRUNO MARIA

Leipzig

Congreso; 51st Annual Meeting of the European Society for Paediatric Endocrinology; 2012

European Society for Paediatric Endocrinology

Background: Endothelial function (EF) is altered in obesity, hypertension, diabetes and metabolic syndrome (MetS), however, few studies were per­formed in children and young. Objective: To determine EF in a young population and its relation to car­diovascular risk factors From outpatient Department of Endocrinology at the Hospital del Niño Jesus Tucumán (July to December 2011), we included children and youth are male and without diabetes, hypertension, history of previous illness, or risk of low weight (BMI percentile <10%). They are di­vided into obese (n = 25) and nonobese (n = 10). Anthropometric parameters, percentage of body fat, blood pressure and laboratory data were measured. EF and arterial stiffness index were measure by reactive hyperemia plethysmo­graph method noninvasive by pulse wave analysis. Results: Had higher body fat percentage and waist circumference. BMI was correlated with the percentage of fat (R2: 0.3415, n = 23). Obese had signifi­cantly higher glucose values. Insulin and HOMA index were altered . EF was higher in non-obese 1.9 ± 2.3% over baseline, n = 9) than in obese (14.4 ± 0.5%, n = 23, P <0.05). Similarly, arterial stiffness index was higher in obeses. In obese this response was negatively correlated with age (R2: 0.2243, n = 23, P <0.05), waist circumference and HOMA index. While both groups had less than 97% percentiles of blood pressure, obesity presented a positive correla­tion between BMI and systolic blood pressure. Conclusions: If well, obeses do not have the diagnostic criteria for MetS, they have insulin resistance, anthropometric measures altered and fat gain. The correlation between BMI and blood pressure in these stages, without hy­pertension, it would mark a tendency to be studied. Obese people have lower FE, indicating early vascular changes and that as they grow more this FE deteriorate. The negative correlation between FE and HOMA index and waist circumference indicating that even without MS, this population already has changes indicating the importance of studying this population, even before this SM, preventing, and the occurrence of cardiovascular disease.