INVESTIGADORES
JOO TURONI Claudio Martin
artículos
Título:
Disparate effect of antioxidant supplements on the basal tone and vascular remodeling of the aorta in hypertensive rats
Autor/es:
MARAÑON RODRIGO; JOO TURONI CLAUDIO; PERAL DE BRUNO MARIA
Revista:
J. VASC. RES.
Editorial:
Karger Journals
Referencias:
Año: 2020
ISSN:
1018-1172
Resumen:
Oxidative stress plays an essential role in the vascular tone in hypertension; however, the mechanisms remain unclear. Aim. To determine the antioxidant effect of tempol and vitamin C (Vit-C) on the basal tone and vascular remodeling of the aorta in nitric oxide (NO)-deficiency-induced hypertensive rats. Method. Male Sprague Dawley rats were induced to hypertension by Nω-nitro-L-arginine methyl ester (L-NAME). Animals were randomized as follows: vehicle (Controls: CR), CR-tempol, CR-Vit-C, L-NAME, L-NAME-tempol, and L-NAME-Vit-C. After six weeks, the basal aortic tone was evaluated by sodium nitroprusside (SNP) and calcium-free medium. Endothelial function, NO, GSH/GSSG ratio, resting membrane potential (mP), and vascular remodeling were also measured. Results. L-NAME rats showed an increased basal tone that was blunted by both SNP (-547±69; n=7 vs. CR: -7.5±6.7mg; n=7; p
