INVESTIGADORES
JOO TURONI Claudio Martin
artículos
Título:
Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic chagas disease
Autor/es:
RAMÓN N. HERRERA; ELBA I. DÍAZ DE AMAYA; ROSSANA C. PÉREZ AGUILAR; CLAUDIO JOO TURONI; RODRIGO MARAÑÓN; SOFÍA G. BERMAN; HÉCTOR L. LUCIARDI; ALFREDO COVIELLO; MARÍA PERAL DE BRUNO
Revista:
CLINICAL APPLIED THROMB/HEMOST.
Editorial:
SAGE PUBLICATIONS INC
Referencias:
Año: 2011 vol. 17 p. 502 - 507
ISSN:
1076-0296
Resumen:
Previously, our group showed a prothrombotic state in asymptomatic patients with chronic Chagas disease. The present paper studies the inflammatory status and endothelial function in these patients. Methods: In forty patients and forty healthy volunteers we evaluated prothrombotic state, blood parasitemia (molecular biology: PCR-amplification), tissue factor pathway inhibitor antibodies (aTFPI), interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1). Endothelial function was determined by reactive hyperemia (pulse plethysmography). Results: In patients, prothrombin fragment 1+2, D-dimer, PAI-1 and fibrinogen were higher. Amplification of 121/122 primers (T. cruzi) was positive in 45% of patients. Patients presented higher values of aTFPI-IgG (p
