Photopolymerizable phospholipids and lipids from lung surfactants in association with mucolytics.

CHIARAMONI, NADIA SILVIA; BUJAN, ARIANA; ALONSO, SILVIA DEL VALLE

Congreso; XLIX Reunión Anual SAB; 2021

Sociedad Argentina de Biofísica

Photopolymerizable phospholipids and lipids from lung surfactants in association with mucolytics.Chiaramoni, N.Sa., Bujan, Aa., Alosno, S. del Va.In the present work, we obtained polymeric diacetylene liposomes1 that can associate N-AcetylL-Cysteine (NAC), a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in the future as NAC delivery systems, with a possible dose reduction but maintaining its effect. Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity. Lipids belonging to lung surfactant2 were added in different ratios to the formulations in order to maximize its possible interaction with the lung tissue.This formulation could efficiently transport NAC to exert its mucolytic. Formulations so obtained presented high levels of polymerization. Also, they present small hollow fibers structures with a high number of polymeric units. These types of arrangements could present advantages in the field of drug delivery, giving the possibility of a controlled release3. Lipopolymers with lipids from lung surfactant associated with NAC are promising complexes in order to treat not only respiratory illnesses. The stability of the formulation would allow its inoculation through other routes such as the oral one, helping the reposition of NAC as an antioxidant drug. 1. Johnston DS, Sanghera S, Pons M, Chapman D. Biochim Biophys Acta - Biomembr. 1980;602(1):57-69. doi:10.1016/0005-2736(80)90289-82. Bernhard W, Hoffmann S, Dombrowsky H, et al. Am J Respir Cell Mol Biol. 2001;25(6):725-731. doi:10.1165/ajrcmb.25.6.46163. Bujan A, Alonso S del V, Chiaramoni NS. Chem Phys Lipids. 2020;231:104936. doi:10.1016/J.CHEMPHYSLIP.2020.104936AgradecimientosCONICET (Grant PIP 11220170100806); UNQ (Grant 990/19).a ? Laboratorio de Bionanotecnología (LBN)- Grupo de Biología Estructural y Biotecnología (GBEyB)- IMBICE-UNQ. Roque Saenz Peña 352- Bernal. Buenos Aires.