Photopolymerizable robust lipids towards reliability and their applications

BUJAN, ARIANA; DEL VALLE ALONSO, SILVIA; CHIARAMONI, NADIA S.

Biophysical Reviews

Springer Nature

Año: 2024

1867-2450

Synthetic lipids have been studied as components in membrane models and drug delivery systems. Polymerizable phospholipids, especially photosensitive ones, can form new bilayer bonds when UV light irradiates. These phospholipids have beenknown since the 1980s, but in the last few years, new applications have been highlighted. Its use in drug delivery systems isinteresting since the photopolymerization reaction produces highly stable vesicles. Additionally, the rearrangement of the acylchains during the photopolymerization process can be applied in the generation of pores, resulting in systems that serve fordrug-controlled release. In this article, our goal was to envision earlier photopolymers’ publications towards the implicationsof these versatile phospholipids that led to proposed systems for drug delivery and controlled release of drugs at specifcsites. This review ofers a broad background towards a simple, reliable, and robust platform to make its application available.