Role of the RNA binding protein IGF2BP1 in cancer multidrug resistance

GOLA, ALDANA MAGALÍ; BUCCI-MUÑOZ, MARÍA; RIGALLI, JUAN PABLO; CEBALLOS, MARÍA PAULA; RUIZ, MARÍA LAURA

BIOCHEMICAL PHARMACOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2024

0006-2952

The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), a member of aconserved family of single-stranded RNA-binding proteins (IGF2BP1-3), is expressedin a broad range of fetal tissues, placenta and more than sixteen cancer types but onlyin a limited number of normal adult tissues. IGF2BP1is required for the transport fromnucleus to cytoplasm of certain mRNAs that play essential roles in embryogenesis,carcinogenesis, and multidrug resistance (MDR), by affecting their stability, translation,or localization. The purpose of this review is to gather and present information on MDRmechanisms in cancer and the significance of IGF2BP1 in this context. Within thisreview, we will provide an overview of IGF2BP1, including its tissue distribution,expression, and molecular targets in the context of tumorigenesis. Our main focus willbe on elucidating the interplay between IGF2BP1 and MDR, particularly with regard tochemoresistance mediated by ABC transporters. Additionally, we will explore thepotential utility of IGF2BP1 inhibitors and related pathways in the field of cancertherapy.