“Effects of Ziprazidone on aggressive behaviour in an animal model”

TORRECILLA N.M.; CASASSA, F.; RODRIGUEZ ECHANDÍA E.L.; RODRÍGUEZ ECHANDÍA E.L

Mar del Plata

Congreso; XXXVII Reunión Anual de la Sociedad Argentina de Farmacología Experimental; 2005

Sociedad Argentina de Farmacología Experimental

EFFECTS OF ZIPRAZIDONE ON AGGRESSIVE BEHAVIOR IN AN ANIMAL MODEL M Torrecilla1, F Casassa1,  C. Fachinelli1, and E.L. Rodríguez Echandía2 1 Laboratorio de Psicología Experimental y Comparada UDA-CRICYT. 2 UNIFCO FCMédicas, UNCuyo. mtorrecilla@lab.cricyt.edu.ar mtorrecilla@lab.cricyt.edu.ar mtorrecilla@lab.cricyt.edu.ar Abstrac Objective: the action of Ziprazidone, an atypical antipsychotic proposed for the treatment of acute aditation, on the behavior of dominants, intermediates and submissive male pigeons in conflictive situation for food competition was investigated. Methodology: fifty pigeons maintained at 80% of their weight were divided in pairs of similar level of dominance for food competition. Twenty three types of behavior were recorded by means of structured observation in ranking sessions of five minutes of interactions. Pigeons were ranked as dominants (n=14), intermediates (n=26) and submissives (n=10) as a function of their total time of aggression. In control sessions each pair received 1 ml of saline sixteen min before the interactions. In the experimental sessions ziprazidone (3 mg/ml) was administered to one of the animals; the other received 1 ml of saline. Results: Dominant pigeons exhibited a significant difference in aggressive behavior (“T” test p<0.05). These was lowered by ziprazidone. Persecution which range 15% of total time in the controls disapeared  in the experimental pigeons. The same occurs with hooking and peacking, the strongest aggressive behavior in pigeons. In intermediate pigeons we found equivalent results. The present study  shows that ziprazidone, a 5-HT D2 dopamine receptors antagonists and inhibitor of 5-HT and NA reuptake inhibits aggression in the animal model of social aggression used.