TORRECILLA Norma Mariana
congresos y reuniones científicas
Behavioral effects of clorimipramine and rewarding treatments in an animal model of depression and basal condition
GARCIA A.; ADARO D.; TORRECILLA N.M.; RODRIQUEZ ECHANDIA E.L.; GONZALEZ JATUFF A
Otro; XXVI Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2008
Sociedad de Biología de Cuyo
Depression is a behavioral, neurochemical and emotional dissorder. Though pharmacological treatments have proved to be effective in this syndrome, reversal may also take place under non pharmacological schedules. In this work a comparisson between chlorimipramine (CIM, 3 mg/kg/day) and chronic aleatory rewarding (CAR), was made after a chronic 14 day aleatory stress exposure (S, Exp 1), and basal conditions (B, Exp 2) in male rats. 24 hs. after the antidepressant treatments (ATD), animals were observed in: 1.- OVM-holeboard (locomocion and exploration). 2.- Plus-maze (ansiogenic performance). 3.- Forced swimming (intra-stress reaction: scapes and inmobility). Animals were kept undisturbed for three weeks, and then challenged with a noise acute stress. Sucaryl preference and corporal weight were periodically recorded. In the 3 tests CIM reversed behavioural post-S deficit better than GRA, but showed little influence in non-stressed rats. In GRA exploration features were increased, both in S and B animals. Only CIM could keep high values of sucaryl preference after withdrawal of ATD. Noise stress reaction was more attenuated in GRA than CIM in S-groups. Both CIM and GRA showed ATD properties, being CIM more effective at the end of treatment. GRA showed a slightly better long-lasting effect. Scared effects were seen under non-stressed condition.